1,644 research outputs found

    Drug resistance

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    Timely Data Delivery in a Realistic Bus Network

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    Abstract—WiFi-enabled buses and stops may form the backbone of a metropolitan delay tolerant network, that exploits nearby communications, temporary storage at stops, and predictable bus mobility to deliver non-real time information. This paper studies the problem of how to route data from its source to its destination in order to maximize the delivery probability by a given deadline. We assume to know the bus schedule, but we take into account that randomness, due to road traffic conditions or passengers boarding and alighting, affects bus mobility. We propose a simple stochastic model for bus arrivals at stops, supported by a study of real-life traces collected in a large urban network. A succinct graph representation of this model allows us to devise an optimal (under our model) single-copy routing algorithm and then extend it to cases where several copies of the same data are permitted. Through an extensive simulation study, we compare the optimal routing algorithm with three other approaches: minimizing the expected traversal time over our graph, minimizing the number of hops a packet can travel, and a recently-proposed heuristic based on bus frequencies. Our optimal algorithm outperforms all of them, but most of the times it essentially reduces to minimizing the expected traversal time. For values of deadlines close to the expected delivery time, the multi-copy extension requires only 10 copies to reach almost the performance of the costly flooding approach. I

    Optical Interconnection Networks Based on Microring Resonators

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    Abstract — Interconnection networks must transport an always increasing information density and connect a rising number of processing units. Electronic technologies have been able to sustain the traffic growth rate, but are getting close to their physical limits. In this context, optical interconnection networks are becoming progressively more attractive, especially because new photonic devices can be directly integrated in CMOS technology. Indeed, interest in microring resonators as switching components is rising, but their usability in full optical interconnection architectures is still limited by their physical characteristics. Indeed, differently from classical devices used for switching, switching elements based on microring resonators exhibit asymmetric power losses depending on the output ports input signals are directed to. In this paper, we study classical interconnection architectures such as crossbar, Benes and Clos networks exploiting microring resonators as building blocks. Since classical interconnection networks lack either scalability or complexity, we propose two new architectures to improve performance of microring based interconnection networks while keeping a reasonable complexity. I

    Optical Interconnection Architectures based on Microring Resonators

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    Abstract: Microring resonators are an interesting device to build integrated optical interconnects, but their asymmetric loss behavior could limit the scalability of classical optical interconnects. We present new interconnects able to increase scalability with limited complexity

    Hereditary and sporadic beta-amyloidoses.

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    Cerebral amyloidoses are chronic, progressive neurodegenerative diseases that are caused by the aggregation and deposition of misfolded proteins in the central nervous system, and lead to cognitive deficits, stroke, and focal neurological dysfunction including cerebellar and extrapyramidal signs. Among them, beta-amyloidoses are a heterogenous set of conditions characterised by the deposition of beta-amyloid protein in brain parenchyma and/or vessel walls that lead to the development of two main clinico-pathological entities: Alzheimer's disease and cerebral amyloid angiopathy, which may be sporadic or familial, and may also co-exist in the same patient. The aim of this review is to describe the most important differences in the pathways leading to parenchymal and cerebrovascular beta-amyloidoses, and the main clinical, neuropathological and biochemical characteristics of the two conditions. It also discusses the phenotypes associated with a series of familial and sporadic beta-amyloidoses in more detail in order to highlight the clinical and neuropathological features that may help to distinguish the different forms of disease

    CA1: PROSPECTIVE ECONOMIC EVALUATION OF ANTIBIOTIC PROPHYLAXIS IN SMALL CELL LUNG CANCER (SCLC) PATIENTS RECEIVING CHEMO THERAPY

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